教授，博士生导师

　　电子邮件（E-mail）：ang.gao@bit.edu.cn

　　电话（Tel）：010-68915451

个人简介：

 高昂，澳门大阳城集团2138网站教授，博士生导师。2019年入选国家级青年人才计划。主要从事细菌与环境相互作用研究，特别聚焦于环二核苷酸信使分子在细菌防御、代谢调控及与宿主互作中的关键核心功能。在相关领域以第一和通讯作者（含共同）发表系统性工作（Cell 2025；Nature 2022；Cell 2018；Nat Commun 2025；Nat Commun 2024；Mol Cell 2019；Nat Chem Bio 2014；Nucleic Acids Res 2020；Nucleic Acids Res 2018）。

简历:

2019至今    北京理工大学，澳门大阳城集团2138网站（教授）

2013-2019   纽约大学，医学院  （博士后）

2008-2013   中国科学院生物物理研究所，生物大分子国家重点实验室 （博士）

2005-2008   山东大学，微生物国家重点实验室 （硕士）

2001-2005   山东大学，生命科学学院 （学士）               

发表文章:

1. Wang J, Li Z, Lang H, Fu W, Gao Y, Yin S, Sun P, Li Z, Huang J, Liu S, Zhu Y, Sun F, Li D, Gao P* & Gao A* (2025). Cyclic dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity. Cell. (in press)

2. Zhang Q#, Zhang X#, Liu K#, Zhu Y, Nie X, Ma J, Sun P, Li Z, Gao Y, Liu S, Gao A*, Zhang L* & Gao P* (2025). Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport. Nat Commun. 16:3146.

3. Huang J#, Zhu K#, Gao Y, Ye F, Li Z, Ge Y, Liu S, Yang J, Gao A* (2024). Molecular basis of bacterial DSR2 anti-phage defense and viral immune evasion. Nat Commun. 15:3954.

4. Zhang Q#, Zhang X#, Zhu Y#, Sun P#, Zhang L, Ma J, Zhang Y, Zeng L, Nie X, Gao Y, Li Z, Liu S, Lou J, Gao A*, Zhang L* & Gao P* (2022). Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature. 612(7938):170-176.

5. Gao A#, Vasilyev N#, Kaushik A, Duan W, Serganov A* (2020). Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH. Nucleic Acids Res. 48(7):3776-3788.

6. Zhu Y#, Gao A#, Zhan Q, Wang Y, Feng H, Liu S, Gao G, Serganov A*, Gao P* (2019). Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins. Mol Cell. 74(2):296-309.

7. Wang Y#, Shi M, Feng H, Zhu Y, Liu S, Gao A*, Gao P* (2018). Structural insights into Non-canonical ubiquitination catalyzed by SidE. Cell. 173(5):1231-1243.

8. Gao A, Vasilyev N, Luciano DJ, Levenson-Palmer R, Richards J, Marsiglia WM, Traaseth NJ, Belasco JG, Serganov A* (2018). Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF. Nucleic Acids Res. 46(13):6841-6856.

9. Peselis A, Gao A, Serganov A* (2016). Preparation and crystallization of riboswitches. Methods Mol Biol. 1320: 21-36.

10. Peselis A, Gao A, Serganov A* (2015). Cooperativity, allostery and synergism in ligand binding to riboswitches. Biochimie. 117: 100-9.

11. Gao A, Sergaov A* (2014). Structural insights into recognition of c-di-AMP by the ydaO riboswitch. Nature Chem Biol. 10(9): 787-92.

12. Gao A, Mei GY, Liu S, Wang P, Tang Q, Liu YP, Wen H, An XM, Zhang LQ, Yan XX*, Liang DC* (2013). High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism of N-acyl homoserine lactonase. Acta Crystallographica Section D. 69(Pt 1): 82-91.

13. Tang Q, Gao P, Liu YP, Liu S, Gao A, An XM, Yan XX*, and Liang DC* (2012). RecOR complex including RecR N-N dimer and RecO monomer displays a high affinity for ssDNA. Nucleic Acids Res. 40(21): 11115-25.